Personalized Medicine with a Nanochemistry Twist by Dipanjan Pan

Author:Dipanjan Pan
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

In the light of exciting reports that demonstrate the role of nanostructural shape in cellular internalisation [59] and prolonged blood circulation [60], nanostructural shape control is emerging as an important strategy to enhance the therapeutic outcome. Also, the nature of self-assembled morphology can dictate the scope of application. For instance, vesicles with hydrophilic internal cavity can serve as a reservoir for hydrophilic components, whereas in the hydrophobic interface it would serve as a barrier for the rapid release of the hydrophilic cargoes. At the same time the hydrophobic interface can also be used for loading hydrophobic drugs, enabling co-delivery of multiple therapeutics with distinct chemical nature [8]. Compared to vesicles made from small-molecule amphiphiles (lipids), vesicles made from block copolymers have been shown to have higher stability and elasticity [11, 61]. Moreover, additional functionalities such as degradability can be easily integrated into the chemistry of vesicle-forming block copolymer, enabling control over the rate of cargo release [62]. Disc-like micelles due to their unique aspect ratio and their strongly segregated core would also be interesting as a nanocarrier for drug delivery applications [63].

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